LymphedemaV1, Main, Exploration, bibRecord, 008E14

Protective immunity in human lymphatic filariasis: problems and prospects.

Identifieur interne : 008E14 ( Main/Exploration ); précédent : 008E13; suivant : 008E15

Protective immunity in human lymphatic filariasis: problems and prospects.

Auteurs : Balachandran Ravindran [Inde] ; Ashok K. Satapathy ; Prakash K. Sahoo ; Madhu Chhanda Mohanty

Source :

Medical microbiology and immunology [ 0300-8584 ] ; 2003.

RBID : pubmed:12592562

Descripteurs français

KwdFr :
- Animaux, Filariose lymphatique (immunologie), Filariose lymphatique (épidémiologie), Humains, Larve (immunologie), Maladies endémiques, Modèles animaux de maladie humaine.
MESH :
- immunologie : Filariose lymphatique, Larve.
- épidémiologie : Filariose lymphatique.
- Animaux, Humains, Maladies endémiques, Modèles animaux de maladie humaine.

English descriptors

KwdEn :
- Animals, Disease Models, Animal, Elephantiasis, Filarial (epidemiology), Elephantiasis, Filarial (immunology), Endemic Diseases, Humans, Larva (immunology).
MESH :
- epidemiology : Elephantiasis, Filarial.
- immunology : Elephantiasis, Filarial, Larva.
- Animals, Disease Models, Animal, Endemic Diseases, Humans.

Abstract

Human filariasis caused by lymphatic dwelling nematodes, affecting 120 million persons worldwide, is a major public health problem. Efforts towards development of vaccines for such large tissue-dwelling nematodes depends significantly on identification and demonstration of protective immunity in the exposed population. Immunological studies conducted in human filariasis so far are essentially attempts to establish a correlation of the immune response phenotypes with presence or absence of filarial infections/disease in the host, and the cause-effect relationship between the observed immune responses in the host and protective immunity continues to be conjectural. This short review attempts to clarify the functional definition of protective immunity, problems associated with identification of putatively immune subjects in endemic areas, role of antibodies reactive to surface of microfilariae and larvae stages of filarial parasites and importance of undertaking immunological investigations on a longitudinal basis in different cohorts of subjects presenting with one or the features of infection and/or disease for more accurate delineation of protective immunity in human filariasis.

DOI: 10.1007/s00430-002-0157-7
PubMed: 12592562

Affiliations:

Inde

Le document en format XML

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<front><div type="abstract" xml:lang="en">Human filariasis caused by lymphatic dwelling nematodes, affecting 120 million persons worldwide, is a major public health problem. Efforts towards development of vaccines for such large tissue-dwelling nematodes depends significantly on identification and demonstration of protective immunity in the exposed population. Immunological studies conducted in human filariasis so far are essentially attempts to establish a correlation of the immune response phenotypes with presence or absence of filarial infections/disease in the host, and the cause-effect relationship between the observed immune responses in the host and protective immunity continues to be conjectural. This short review attempts to clarify the functional definition of protective immunity, problems associated with identification of putatively immune subjects in endemic areas, role of antibodies reactive to surface of microfilariae and larvae stages of filarial parasites and importance of undertaking immunological investigations on a longitudinal basis in different cohorts of subjects presenting with one or the features of infection and/or disease for more accurate delineation of protective immunity in human filariasis.</div>
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Serveur d'exploration sur le lymphœdème

Protective immunity in human lymphatic filariasis: problems and prospects.

Protective immunity in human lymphatic filariasis: problems and prospects.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration sur le lymphœdème
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